Running profiles 'locally' gives you the opportunity to run your HL7 Listener as a desktop application right from within the configuration program. Doing this has advantages and disadvantages. It's nice in that you have a nice user interface and can actually SEE your listeners run. The big disadvantage is that desktop applications are not fault tolerant and can't be configured to start up automatically when the system boots up as a Windows service application can.
To run your listener locally click the 'Run Listener Profiles Locally' button in the 'Windows Service Status' tab (see below) or from the menu on the main toolbar.
This will bring up the local processing window. Click the 'Run' button () on the toolbar of this window to start your listener(s).
While profiles are running you can click the 'Stop' button () at any time to halt your profile(s).